Alzheimer’s, Related Disorders and Autophagy

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Alzheimer’s disease remains one of the biggest medical and socio-economic challenges for our aging society. The disease places a tremendous burden on both individual patients and their caring families. The most common form of Alzheimer’s disease is strictly based on age with no clear-cut family history, but other types of the disease exist such as rare, genetic forms that appear early in one’s life. Despite huge efforts in both basic and clinical research there is no causal Alzheimer’s therapy currently available or in immediate sight.

In the last three decades researchers have learned a great deal about the biochemistry of the proteins and mechanisms associated with Alzheimer’s and related neurodegenerative disorders. Strong evidence suggests that a disturbance of protein homeostasis in the neurons of the brain ultimately leads to neuronal dysfunction and degeneration.

In recent years, autophagy, which is the intracellular degradation process responsible for the clearance of cellular junk, non-functional proteins and organelles that disturb cell structure and function, particularly in neurons, has gained a lot of attention in Alzheimer ’s research. The 2016 Nobel Prize for Physiology or Medicine was even awarded to the Japanese researcher Yoshinori Ohsumi in for his uncovering of the key mechanisms of autophagy.

The workshop on “Alzheimer’s, Related Disorders and Autophagy” brings together a small group of experts from the U.S. and Germany for a day of scientific exchange on the topics of neurodegeneration and autophagy. These experts will present their data and opinions on the importance and relevance of autophagy on neurodegeneration to a group of interested students, an informed audience as well as invited colleagues, and a constructive discussion is expected. This day of German-American scientific exchange will address current scientific knowledge with an eye on addressing whether the targeting of autophagy is an effective prevention or therapy for Alzheimer’s and related disorders in the future.

The workshop is organized and chaired by Christian Behl from the University Medical Center of the Johannes Gutenberg University Mainz, Germany and Ralph Nixon of the Nathan S. Kline Institute for Psychiatry and NYU Langone Medical Center, USA in close cooperation with the German Center for Research and Innovation New York. Funding of this workshop by the Dr. Eberhard Strebel-Stiftung and support by the University Medical Center Mainz is gratefully acknowledged.

The workshop is chaired by

Christian Behl, PhD
University Medical Center, Johannes Gutenberg University Mainz

and

Ralph Nixon, PhD
Nathan S. Kline Institute for Psychiatry and NYU Langone Medical Center

Event Information

October 24, 2019, 9:00 AM to 6:00 PM

German House, New York
Organizer: German Center for Research and Innovation (DWIH NY)

This event is by invitation only.

Location

German Center for Research and Innovation New York

Address: 871 United Nations Plaza
New York, NY 10017, USA

Phone: +1 (212) 339 8680
Email: